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2 edition of Mucociliary clearance and asthma found in the catalog.

Mucociliary clearance and asthma

Thomas G. O"Riordan

Mucociliary clearance and asthma

the relevance of mucociliary clearance measurements to clinical asthma

by Thomas G. O"Riordan

  • 273 Want to read
  • 27 Currently reading

Published .
Written in English


Edition Notes

Thesis (M.D.) - University College Dublin, National University of Ireland, 1993.

StatementThomas G. O"Riordan.
ID Numbers
Open LibraryOL20222686M

ciliary clearance compared to normal controls Si-nusitis symptomatology may, therefore, be created and sustained by changes in mucus structure and re-duced mucociliary transport. Chronic Sinusitis and the Fungal Connection – Allergic Fungal Sinusitis Chronic sinusitis results in local non-invasiveFile Size: KB. The removal of inhaled particles, endogenous cellular debris, and excessive secretions from the tracheobronchial tree by the action of the ciliated cells that live in the respiratory tract. Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in Author: Pierachille Santus, Dejan Radovanovic, Davide Alberto Chiumello. Effect of Removing Vagal Control on Mucociliary Clearance in a Murine Model. BL Laube, AR Bhashyam, JC Cleary, BJ Undem, M Kollarik, J Fox, and PJ Mogayzel, Jr Increased Postoperative Respiratory Complications in Patients with Congenital Heart Disease and Heterotaxy.


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Mucociliary clearance and asthma by Thomas G. O"Riordan Download PDF EPUB FB2

Duncan F. Rogers, in Asthma and COPD (Second Edition), Asthma. Airway mucociliary clearance is well documented as being impaired in asthma [72]. Clearance is impaired even in patients in remission [81] and in those with mild stable disease [82].

Mucus clearance is proportionally reduced in symptomatic asthmatics [83] and during. Mucociliary clearance (MCC), mucociliary transport, or the mucociliary escalator, describes the self-clearing mechanism of the airways in the respiratory system.

It is one of the two protective processes for the lungs in removing inhaled particles including pathogens before they can reach the delicate tissue of the lungs. The other clearance mechanism is provided by the cough : D Mucociliary Clearance in Asthma and COPD Clearance of mucus from the airways is impaired in patients with a variety of respiratory diseases, including asthma and COPD [73].

However, it should be noted that there are often discrepancies in results between studies that are invariably due to differences in methodology [74, 75], but may also be.

Mucociliary clearance (MCC) is one of the most important nonspecific defense mechanisms of the respiratory tract, and its impairment is a well-documented feature of chronic respiratory diseases, including asthma.

In vitro and in vivo data suggest that several inflammatory mediators influence the mucociliary apparatus. Mucociliary clearance (MCC) is one of the most importantnonspecific defense mechanisms of the respiratory tract, and itsimpairment is a well-documented feature of chronic respiratorydiseases, including asthma.

In vitro and in vivo data suggest that severalinflammatory mediators influence the mucociliary apparatus. Epithelialdamage and functional abnormalities have been described in Cited by: Tracheobronchial mucociliary clearance was measured in eight non-smoking patients with asthma in complete remission.

The patients were symptom free and required no medication whatsoever for one to six months before assessment. Mucociliary clearance Cited by: The effect of inflammation on mucociliary clearance asthma: An overview Article Literature Review (PDF Available) in Chest (4) November with 53 Reads How we measure 'reads'.

Upper respiratory tract viral infection and mucociliary clearance. Wilson R, Alton E, Rutman A, Higgins P, Al Nakib W, Geddes DM, Tyrrell DA, Cole PJ.

Twenty-six normal volunteers were exposed to rhinovirus or influenza B by: Airway mucus is a viscoelastic gel containing water, carbohydrates, proteins, and lipids. It is the secretory product of the mucous cells (the goblet cells of the airway surface epithelium and the submucosal glands).

Mucus is transported from the lower respiratory tract into the pharynx by. "Mucociliary clearance in the airways." American journal of respiratory and critical care medicine, (6), pp.

–Cited by: Lung mucociliary clearance rates are reduced during sleep in patients with asthma. Methylxanthines and beta 2 agonists have been shown to enhance rates of lung mucociliary clearance.

Asthma affects approximately million people worldwide and causes approximatelydeaths annually ().Tracheobronchial mucociliary clearance is impaired in stable asthma and worsens during acute exacerbations ().The principal cause of death from asthma is asphyxiation from intraluminal airway obstruction by widespread mucus plugs (4 – 6).

Isawa T, Teshima T, Hirano T, Ebina A, Konno K () Mucociliary clearance mechanism in interstitial lung disease. Tohoku J Exp Med – PubMed CrossRef Google Scholar mucociliary clearance: the movement of the mucous covering of the respiratory epithelium by the beating of cilia: rapid, forward (effective) stroke and slow, return (recovery) stroke.

In the nose, mucus is moved toward the pharynx. In the tracheobronchial tree, mucus is moved toward and through the larynx and swallowed.

Synonym(s): mucociliary. mucociliary clearance. In established disease, there is a vicious cycle of inflammation driven by neutrophils, recurrent or persistent infection, primarily with Haemophilus influenzae and injury to epithelium and bronchial and bronchiolar structures (figure 2).

The anatomical damage further impairs mucociliary clearance. Introduction. Pneumonia is the leading infectious cause of death in the elderly.

Impaired respiratory defences are one of the causes for increased susceptibility of the elderly to such infections. Nasal mucociliary clearance, the mirror image of bronchial clearance, is crucial in respiratory defence and is affected by various by: 6.

Reserve your copy now. This two volume book is an outstanding reference source on all aspects of allergy and allergic diseases. Covering virtually every allergic condition, from the immunological and molecular basis of the allergic response to future trends in allergic disease prevention, this new international editorial team (, Jean Bousquet, Pat Holt and Allen Kaplan) have.

The objective of this study was to investigate whether reduced bronchial mucus transport velocity (BTV) is associated with a loss of cilia or ultrastructural abnormalities of cilia in intubated patients.

The patients were studied prospectively in a convenience sample trial. The study took place in a university hospital. 29 orally intubated patients in a surgical by: A theoretical model of the movement of aerosols in the lungs is proposed. The model is based upon the transport equations taking into account the aerosol inertial deposition processes.

Particles move along curvilinear trajectories in self-twisted vortex air flows. Deposition occurs over several cycles of inhalation and exhalation. This mechanism works for particles with a diameter greater than Author: Gennady Fedorovitch. Invited Review Mucociliary and Cough Clearance as a Biomarker for Therapeutic Development William D.

Bennett, Ph.D.,1 Evangelia Daviskas, Ph.D.,2 Amir Hasani Ph.D.,3 Jann Mortensen, M.D.,4 John Fleming Ph.D.,5 and Gerhard Scheuch, Ph.D.6 Abstract A workshop/symposium on ‘‘Mucociliary and Cough Clearance (MCC/CC) as a Biomarker for Therapeutic.

Normal Clearance. Normal airway clearance requires a patent airway, a functional mucociliary escalator, and an effective cough.

5,19,20 Airways normally are kept open by structural support mechanisms (see Chapter 8) and kept clear by proper function of the ciliated mucociliary clearance mechanism operates from the larynx down to the respiratory bronchioles.

The multiscale mechanics of mucociliary transport in the human airways. MCC is powered by an estimated 2 × 10 12 motile cilia that propel a layer of mucus towards the larynx [3,4].Healthy airway epithelia contain mostly multiciliated cells and are covered with an airway surface liquid (ASL) consisting of two components, a mucus layer near the tip of the cilia that is propelled by the Cited by: 1.

People with asthma and GER (9% of asthmatics had GER) had more nocturnal cough and morning phlegm with sleep-related symptoms. 9 The authors concluded that there was a strong association between asthma and GER. Cigarette smoking is known to stop mucociliary clearance. Plastic bronchitis (PB) is a disorder in which branching casts of the airways are is not a single disease with a defined mechanism that explains the cast formation in all conditions.

Examples of diseases associated with expectoration of casts, and which sometimes are labeled PB include tuberculosis, atypical mycobacterial disease, allergic bronchopulmonary aspergillosis and lty: Respirology. To enter the study, individuals with a suspected mucociliary clearance defect (n=) must be age 2 years or older and meet one of the 4 following profiles: Have known or suspected nontuberculous mycobacterial lung disease and enrolled in Protocol I, Natural History, Genetics, Phenotype, and Treatment of Mycobacterial Infections.

Mucociliary clearance (MCC) is an integral part of lung defense mechanisms, enabling efficient clearance of inhaled particles, including microorganisms, from the respiratory tract [1, 2].Airway infections and ciliary dysfunctions can lead to impaired mucus transport [3, 4] and can thereby enhance the fraction of retained particles, including microorganisms in the by: The degree of airway inflammation is directly related to asthma severity and associated hyper-responsiveness.

Airway inflammation is categorized into three types: (a) acute asthmatic inflammation featured by early recruitment of cells into the airways, (b) subacute asthmatic inflammation involving activation of recruited cells in continual inflammation, and (c) chronic inflammation Author: Poonam Arora, S.H.

Ansari. BACKGROUND: Exposure to cigarette smoke causes significant impairment in mucociliary clearance (MCC), which predisposes patients to secretion retention and recurrent airway infections that play a role in exacerbations of COPD.

To determine whether smoking cessation may influence MCC and frequency of exacerbations, the following groups were evaluated: ex-smokers with. mucociliary clearance and, Air pollution book review Air, the environment, and public health (Kessel AS), 70 Airway clearance. See Mucociliary clearance A irway obstruction airway stents for respiratory failure from central airway collapse, congenital, mucociliary clearance in children with, endotracheal cuff deflation in high.

Maurizio Vignola was a superb and innovative researcher, who wrote seminal papers on the biology of airway epithelium in asthma. Inflammation and remodelling were the main topics of his research, mostly conducted in biopsy specimens from patients with asthma of variable severity, encompassing the entire spectrum of the disease from mild to severe by: 9.

Drugs acting on respiratory system RESPIRATORY DISEASES Asthma Allergic rhinitis Chronic obstructive pulmonary disease Cough 3. these effects may enhance mucociliary clearance, and thereby reverse the defective clearance found in asthma.

Start studying Chapter 6 - Rau's Respiratory Pharmacology. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. and especially asthma mortality, DESPITE all of the advances in the understanding and drugs for asthma Tx with some inhibtion of inflammatory mediator release and stimulation of mucociliary.

@article{osti_, title = {Lung mucociliary transport during high-frequency ventilation}, author = {McEvoy, R.D. and Davies, N.J. and Hedenstierna, G. and Hartman, M.T. and Spragg, R.G.

and Wagner, P.D.}, abstractNote = {The effects of high-frequency, low-tidal-volume ventilation (HFV) and conventional intermittent positive-pressure ventilation (IPPV) on lung mucociliary transport were.

The self cleansing system of the upper respiratory tract - the mucociliary clearance - is a constant stream of mucilage propelled towards the oral structures by the waving of fine cilia.

The importance and measurement of clearance is shown, together with measuring the rate of clearance using a new method on rabbit trachea. The effects of drugs (Ozothin) and pollution (smoking) on clearance.

clearance 1. the disposal of merchandise at reduced prices b. (as modifier): a clearance sale 2. the act of clearing an area of land of its inhabitants by mass eviction 3. Dentistry the extraction of all of a person's teeth 4.

a less common word for clearing Clearance the maximum profile of an object. As applied to transport vehicles and the moving. In CF, impairment of mucociliary clearance is the result of abnormal airway hydration due to CF transmembrane regulator (CFTR) mutations.

In PCD it is due to abnormal structure and function of cilia. In other groups of patients with bronchiectasis, it is assumed that infection and/or perturbed innate or acquired immunity are important factors.

Mucolytics are used to reduce mucus viscosity and improve mucociliary clearance. Corticosteroids and nonsteroidal antiasthma agents are used to. Results: The average mucociliary clearance time was significantly different, and minutes in cases and controls respectively (p = ).Cited by: 1.

Genetic Disorders of Mucociliary Clearance Book Chapters 1. Knowles MR, Morillas HN, Leigh M, Zariwala M. Primary ciliary dyskinesia. In: Rounds S, ed. Molecular Basis of Lung Disease, Insights from Rare Lung Disorders. Totowa, NJ: Humana Press; Abstracts Presented at Conferences 1.

Determination of nasal mucociliary clearance time and nasal symptom in patients with crimean-congo hemorrhagic fever. J Med Virol Nov 3. [14] de Oliveira-Maul JP, de Carvalho HB, Miyuki Goto D, Mendonça Maia R, Fló C, Barnabé V, et al.

Aging, diabetes and hypertension are associated with decreased nasal mucociliary by: 1. Wanner A. Autonomic Control of Mucociliary Clearance.

In "The Airways: Neural Control in Health and Disease", Kaliner M, Barnes P (eds), (Vol. 33 - Lung Biology in.Treatment of Mucus Hypersecretion in Asthma. The goals of treatment for mucus hypersecretion in asthma should be to reduce mucus volume, normalize mucus composition, and improve mucus clearance.

The effects of currently available antiasthma medications on mucus volume, mucus composition, or mucus clearance are largely unknown, however, because these outcomes are difficult .Related to mucociliary clearance: mucociliary clearance rate CLEARANCE, com.

law. The name of a certificate given by the collector of a port, in which is stated the master or commander (naming him) of a ship or vessel named and described, bound for a port, named, and having on board goods described, has entered and cleared his ship or vessel.